CHOREA; RHEUMATISM; MANY LARGE SUBCUTANEOUS NODULES ; MITRAL REFLUX; GOOD RECOVERY.

The Subcutaneous Nodule of Rheumatism

Subcutaneous Rheumatoid Nodules.

death to give reliable results. The postmortem interval as already defined established fixed limits for the interval and avoided possible overestimation of the amino acid concentration relative to time after death. Analysis of the results showed no evidence that a specific aminoacidopathy is implicated in the aetiology of cot death but has nevertheless improved our understanding of the biochemi...

Subcutaneous rheumatoid nodules.

We describe seven children with subcutaneous rheumatoid nodules who had no clinical evidence of rheumatoid arthritis. Only one girl was seropositive for antinuclear factors and had a slightly raised erythrocyte sedimentation rate. Clinical aspects, risks for developing rheumatoid arthritis, and treatment of this entity are discussed.

Subcutaneous nodules of Still's disease.

The observations of Collins (1937) and of Bennett, Zeller, and Bauer (1940) established clearly the pathological differentiation of the ordinary subcutaneous nodules in rheumatic fever and in rheumatoid arthritis. In brief, the rheumatic fever nodule is characterized by much fibrinoid material arranged in a lattice with apparently clear spaces between the strands, considerable oedema, but relat...

Immunopathology of subcutaneous rheumatoid nodules.

Nodules obtained from five patients with classical seropositive rheumatoid arthritis were studied by an immunofluorescence technique using polyclonal antibodies to IgG, IgA, IgM, C3c, and fibrin, and monoclonal antibodies to the terminal (C5b-9) complement complex (reaction with a neoantigen in C9 revealed during activation), DR antigens, T cells, macrophages, and interdigitating cells. In all ...